High BTLA Expression Likely Contributes to Contraction of the Regulatory T Cell Subset in Lupus Disease
B Grip Sensor Wire and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor that is expressed by lymphoid cells and regulates the immune response.Consistent with an inhibitory role for BTLA, the disease is exacerbated in BTLA-deficient lupus mice.We recently demonstrated that the BTLA pathway is altered in CD4+ T cells from lupus patients.In